Mda Mb 231 Cells Characteristics

The mda mb 231 cell line isolated at m d anderson from a pleural effusion of a patient with invasive ductal carcinoma is commonly used to model late stage breast cancer.

Mda mb 231 cells characteristics. During emt epithelial cells lose their polarity as well as their cell cell adhesions and acquire the motile and invasive characteristics of mesenchymal cells hay 1995. Proteins such as vimentin vim intermediate filament if are generally upregulated when the cell is in the mesenchymal relative to the epithelial status gilles et al. 3 both adenosine mediated responses in mda mb 231 cells were observed with the nonselective agonists 5 n ethylcarboxamidoadenosine neca and 2 3 hydroxy 3 phenyl propyn 1 yladenosine 5 n ethyluronamide phpneca but no. Mda mb 231 cells showed both a stimulation of adenylyl cyclase and a plc dependent increase in intracellular ca 2 in response to nonselective adenosine receptor agonists.

Mda mb 231 cells in culture. In microarray profiling the mda mb 231 cell genome clusters with the basal subtype of breast cancer. Mda mb 231 atcc htb 26 homo sapiens mammary gland breast. This cell line is er pr and e cadherin negative and expresses mutated p53.

The mda mb 231 cell line is aepithelial n human breast cancer cell line that was established from a pleural effusion year old caucasian femaleof a 51 with a metastatic mammary adenocarcinoma1 and is one of the most commonly used breast cancer cell lines in medical research laboratories. Faq s morphology of atcc htb 26 the atcc htb 26 cell line is. Thiery and sleeman 2006.