Mda Mb 231 Cell Line Wikipedia

Mcf 7 is the acronym of michigan cancer foundation 7 referring to the institute in detroit where the cell line was established in 1973 by herbert soule and co workers.

Mda mb 231 cell line wikipedia. This cell line is er pr and e cadherin negative and expresses mutated p53. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. In microarray profiling the mda mb 231 cell genome clusters with the basal subtype of breast cancer. The cells are somewhat spindle.

The mda mb 231 cell line isolated at m d anderson from a pleural effusion of a patient with invasive ductal carcinoma is commonly used to model late stage breast cancer. A new combination of sulforaphane a natural compound obtained from brassicaceae vegetables and the cytostatic drug doxorubicin was entrapped in nanometer sized liposomes. This enables the tracking of the emt status of cells in vitro by. The mda mb 231 cell line is aepithelial n human breast cancer cell line that was established from a pleural effusion year old caucasian femaleof a 51 with a metastatic mammary adenocarcinoma1 and is one of the most commonly used breast cancer cell lines in medical.

Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. The cell line is aneuploid female modal number 64 range 52 to 68 with chromosome counts in the near triploid range. In vitro experiments were performed to investigate the cytotoxicity of these structures on the human breast cancer cell line mda mb 231. The mda mb 231 cell line is also able to grow on agarose an indicator of transformation and tumorigenicity and displays a relatively high colony forming efficiency.

The vim rfp reporter cell line atcc htb 26met was created using crispr cas9 gene editing and the parental mda mb 231 breast adenocarcinoma cell line atcc htb 26. This is a list of major breast cancer cell lines that are primarily used in breast cancer. Review and cite mda mb 231 cell line protocol troubleshooting and other methodology information contact experts in mda mb 231 cell line to get answers. Cell line profile.

Faq s morphology of atcc htb 26 the atcc htb 26 cell line is epithelial like. 92020424 cell line history. Mda mb 231 was isolated from pleural effusions of a caucasian breast cancer patient. In vivo the mda mb 231 cells form mammary fat pad tumors in nude mice.

Htb 26met harbors a c terminal red fluorescent protein rfp tag on the vimentin gene.